| Catalog Number | TM-1201Z-55 |
| Product Id | TM-1201Z-55 |
| Product Name | Anti-human Suppressor of RNA Polymerase B (SRB7) IgG fraction(monoclonal) |
| Temperature | -20°C |
| Unit | 150µg |
| Price | 425 |
| Availability | Available |
| Category | Proteins and Antibodies for Transcription Research |
| Subcategory | Proteins and Antibodies |
| Description | IgG fraction from mouse monoclonal antibody (clone 5G12/H8) obtained by immunization of mice with a recombinant human SRB7 (15 kDa). The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG1 |
| Purity | N/A |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing |
| Biological Activity | This antibody can be used in ELISA assays (1: 8,000 dilution) and Western blot (1: 8,000 dilution)). It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors. |
| Formulation | Solution at 1.0 mg/mL in PBS |
| References | Myers, L.C. & Kornberg, R. D. (2000) Annu. Rev. Biochem. 69, 729 – 749 ; Gu, W. et. al. (1999) Mol. Cell 3, 97 – 108 ; Sun, X. et. al. (1998) Mol. Cell 2, 213 – 222; Maldonado, E. et. Al. (1996) Nature 381, 86 – 89. |
