| Catalog Number | TM-1421Z-55 |
| Product Id | TM-1421Z-55 |
| Product Name | Anti-human Di-Methyl K9 Histone H3 (DI-Methylated H3 K9) IgG fraction(monoclonal) |
| Temperature | -20°C |
| Unit | 150µg |
| Price | 425 |
| Availability | Available |
| Category | Proteins and Antibodies for Transcription Research |
| Subcategory | Proteins and Antibodies |
| Description | IgG fraction from mouse monoclonal antibody (clone 4H6/A10) obtained by immunization of mice with a KLH-conjugated synthetic peptide KQTAR[dimethyl-K]STGGK-C corresponding to aa4 – aa14 of human histone H3. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG1 |
| Purity | N/A |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing |
| Biological Activity | This antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes dimethylated H3 K9. The methylation of specific histone lysines controls aspects of short- and long-term transcriptional regulation, in addition to the propagation of bulk chromosome structure and stability. Methylated histone H3 K9 is also involved in transcriptional silencing of human polycomb target genes and epigenetic imprints of the inactive X-chromosome . Methylated H3 K9 is considered a mark of repressive chromatin state |
| Formulation | Solution at 0.5 mg/mL in PBS |
| References | Schotta, G. et. al. (2004) Genes & Dev. 18, 1251 – 1262 ; Rougeulle, C. et al. (2004) Mol. Cell. Biol. 24, 5475 – 5484; Sims, R. J. et. al. (2003) Trends Genet. 19, 629 – 639; Hampsey, M & Reinberg, D. (2003) Cell 113, 429 – 432. |
