| Catalog Number | TM-1801Z-55 |
| Product Id | TM-1801Z-55 |
| Product Name | Anti-Dimethylated human Tumor Suppresor p53 IgG fraction (monoclonal) |
| Temperature | -20°C |
| Unit | 150µg |
| Price | 425 |
| Availability | Available |
| Category | Proteins and Antibodies for Transcription Research |
| Subcategory | Proteins and Antibodies |
| Description | IgG fraction from mouse monoclonal antibody (clone 2D12/E8) obtained by immunization of mice with a KLH-conjugated synthetic peptide SHLKS [dimethyl-K]KGQST corresponding to aa367 – aa377 of human tumor suppressor p53. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG1 |
| Purity | N/A |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing |
| Biological Activity | This antibody can be used in ELISA assays (1: 1,000 dilution). It recognizes dimethylated p53 (K372). p53 is a transcription factor that is mutated in approximately half of all human cancers. It controls the cell cycle, apoptosis and DNA repair in response to cytotoxic stresses. The C terminus of p53 is rich in lysines, which are subjected to different modifications to regulate p53 activity |
| Formulation | Solution at 1.0 mg/mL in PBS |
| References | Chuikov, S. et .al. (2004) Nature 432, 353 – 360 ; Hupp, T.R. et. al. (1992) Cell 71, 875 – 886 ; Malkin, D. et. al. (1990) Science 250, 1233 – 1238. |
