| Catalog Number | MA-CD45-6 |
| Product Id | MA-CD45-6 |
| Product Name | Anti-human CD45 (Leukocyte Common Antigen) IgG fraction (monoclonal) |
| Temperature | -20°C |
| Unit | 200µg |
| Price | 275 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Monoclonal Antibodies (Immunology Antigens) |
| Description | IgG fraction from mouse monoclonal antibody (clone 8G3/A1) obtained by immunization of mice with human lymphocytes. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG2a |
| Purity | N/A |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing |
| Biological Activity | This antibody can be used in flow cytometry studies. It recognizes all isoforms of the CD45 (LCA). CD45 is a transmembrane tyrosine phosphatase, expressed on nucleated hematopoitic cells, which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing. CD45 functions as a leukocyte membrane receptor signal transduction. It plays an essential role in the regulation of leukocyte activation, development, and function. |
| Formulation | Solution at 1.0 mg/mL in PBS |
| References | Mustelin, T. et al. (2004) Mol. Immunol. 41, 687 – 700 ; Trowbridge, I.S. et. al. (1994) Annu. Rev. Immunol. 12, 85 – 116 ; Justement, L.B. et. al. (1991) Science 252, 1839 – 1842. |
