| Catalog Number | PCA-2000a-9 |
| Product Id | PCA-2000a-9 |
| Product Name | Rabbit anti-Human Cullin1 (CUL 1) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Apoptosis) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DGEKDTYSYLA) corresponding to amino acids 742-752 of human Cullin 1. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA (1:50 dilution) using the immunizing peptide. Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 1 (CUL 1) is an essential component of SCF E3 Ubiquitin ligase complex which mediates the ubiquitation of proteins involved in cell cycle progression, signal transduction and transcription. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Michel, J.J. & Xiong, Y. (1998) Cell Growth Differ. 9, 435-449. Zheng, N. et al. (2002) Nature 416, 703-709. Jackson, P.K. & Eldridge, A.G. (2002) Mol. Cell. 9, 923-925. |
