| Catalog Number | PCA-2005a-9 |
| Product Id | PCA-2005a-9 |
| Product Name | Rabbit anti-Human Cullin2 (CUL 2) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Apoptosis) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (RSQASADEYSYVA) corresponding to amino acids 733-745 of human Cullin 2. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA (1: 100 dilution) and Western blot (1: 1,000) using the immunizing peptide. Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 2 (CUL 2) is a component of E3 ubiquitin ligase complexes which controls the proteolysis of G1 cell cycle regulatory proteins. It forms a complex with an inactive transcriptional elongation complex formed by three subunits elongain C, elongain B and VHL. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Michel, J.J. & Xiong, Y. (1998) Cell Growth Differ. 9, 435-449. Liakopoulos, D. et al. (1999) Proc. Natl. Acad. Sci. USA 96, 5510-5515. |
