| Catalog Number | PCA-2090a-9 |
| Product Id | PCA-2090a-9 |
| Product Name | Rabbit anti-Human Beta-Catenin IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Apoptosis) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (SYLDSGIHSGATTTAPSLSGK) corresponding to amino acids 29-49 of human beta-catenin. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot (1: 2,000 dilution) using the immunizing peptide. The catenins are structurally related cytoplasmic proteins which have been classified as alpha (102-105 kDa), beta (92-97 kDa), and gamma (82-86 Kda). Beta-Catenin plays an important role in the cadherin-mediated anchoring and organization of the cytoskeleton. It is also involved in regulation of gene expression as a mediator of the Wnt signalling pathway. Beta-Catenin associates with the tumor suppressor protein APC and it is implicated in early embryonic development and tumorogenesis. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Willert, K. & Nusse, R. (1998) Curr. Opin. Genet. Dev. 8 (1), 95-102. Kikuchi, A. (2000) Biochem. Biophys. Res. Commun. 268 (2), 243-248. Willert, K. & Jones, K.A. (2006) Genes Dev. 20, 1394-1404. |
