| Catalog Number | PCA-2135a-9 |
| Product Id | PCA-2135a-9 |
| Product Name | Rabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Apoptosis) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (VLIVIFTVLLQSLCVAVTY) corresponding to amino acids 17-35 of human TRAIL. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot (1:100 dilution) using the immunizing peptide. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or Apo-2 ligand is a cytokine that belongs to TNF family and induces apoptosis of tumor cells by binding to its receptors, TRAIL R1 (DR4) and TRAIL R2 (DR5). Both Receptors contain death domains and two decoy receptors TRAIL-R3 (DcR1) and TRAIL-R4 (DcR2) that inhibit TRAIL function. TRAIL induces apoptosis and NF?B activation in many tissues and cells. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Wiley, S.R. et al. (1995) Immunity 3, 673-682, Pitti, R.M. et al. (1996) J. Biol. Chem. 271, 12687-12690. Wang, S. & El-Deiry, W.S. et al. (2003) Oncogene 22, 8628-8633. |
