| Catalog Number | PCA-2137a-9 |
| Product Id | PCA-2137a-9 |
| Product Name | Rabbit anti-Human Tumor Necrosis Factor-related apoptosis-inducing ligand Receptor 2 (TRAIL R2) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Apoptosis) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (LGERLAKQKIEDHLLSSGK) corresponding to amino acids 409-427 of human TRAIL R2. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot (1:500 dilution) using the immunizing peptide. Tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL R2 or TRICK 2) or also termed death receptor 5 (DR5) is a type I membrane protein that contains a cytoplasmic death domain. It binds TRAIL and mediates apoptosis via intracellular adaptor molecule FADD/MORT 1 and activation of NF?B. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Schneider, P. et al. (1997) FEBS Lett. 416, 329-334. Walczak, H. et al. (1997) EMBO J. 16, 5386-5397. Suliman, A. et al. (2001) Oncogene 20, 2122-2133. Falschlehner, C. et al. (2007) Int. J. Biochem. Cell Biol. 39, 1462-1475. |
