| Catalog Number | PN-7010a-9 |
| Product Id | PN-7010a-9 |
| Product Name | Rabbit anti-Human Beta- Synuclein IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Neurobiology) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (IEPLMEPEGESYEDPPQE) corresponding to amino acids 108 - 125 of human Beta-Synuclein. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Human beta synuclein is a soluble protein highly abundant in presynaptic nerve terminals and a member of the synuclein family. It could act as a physiological negative regulator of Alpha-Synuclein aggregation and it is associated with neurodegenerative disordes.This protein has been shown to be a substrate for phosphorylation by CAM kinase. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Jakes, R. et al. (1994) FEBS Lett 345, 27 - 32. Clayton, D.F. & George, J.M. (1998) Trends Neurosci. 21 (6), 249 254. George, J.M. (2002) Genome Biol.3, 3002.1 - 3002.6. Masliah, E. & Hashimoto, M. (2002) Neurotoxicology 23, 461 - 468 |
