| Catalog Number | PN-7040a-9 |
| Product Id | PN-7040a-9 |
| Product Name | Rabbit anti-Human Synphilin-1 (Alpha Synuclein-Interacting protein, SNCAIP) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Neurobiology) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (ASKGKNKAA) corresponding to amino acids 911 - 919 of human Synphilin-1. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western Blot using the immunizing peptide. Synphilin-1 is a cytoplasmatic protein that interacts with Alpha-Synuclein in neurons, and plays an important role in synaptic function, protein degradation and Lewy body formation. Mutation of this protein has a role in the formation of aggregates and cytotoxicity in Parkinson's desease by defective ubiquitination and /or proteosomal inhibition. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Engelender, S. et al. (1999) Nat. Genet. 22, 110 - 114. Hrüger, R. (2004) Cell Tissue Res. 318, 195 - 199. |
