| Catalog Number | PN-7085a-9 |
| Product Id | PN-7085a-9 |
| Product Name | Rabbit anti-Human Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Neurobiology) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DLPNSGGEAQAKKLGNN) corresponding to amino acids 41-57 of human ERAB. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot assays (1: 1,000 dilution) using the immunizing peptide. Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27 kDa protein, member of the short-chain dehydrogenase/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Yan, S.D. et al. (1997) Nature 389, 689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273, 10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451, 238-242. |
