| Catalog Number | PN-7120a-9 |
| Product Id | PN-7120a-9 |
| Product Name | Rabbit anti-Human PARK 7 (DJ-1) IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Neurobiology) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AAQVKAPLVLKD) corresponding to amino acids 178-189 of human PARK 7. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody can be used in ELISA (1:1,000 dilution), immunicytochemistry (1:100 dilution) and it recognizes PARK 7 (20 kDa) in Western blot of HeLa lysate(1:1,000 dilution). PARK 7, also known as DJ-1 is a highly conserved cytoplasmatic protein and acts as a positive regulator of androgen receptor-dependent transcription. The expression of PARK 7 is induced by growth signals, and it is translocated from the cytoplasm to nucleous during S-phase of the cell cycle. PARK 7 also may fuction as redox-sensitive chaperone and as sensor for oxidative stress. Mutations in PARK 7 are associated with the autosomal recessive early-onset Parkinson's disease. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Nagakubo, D. et al. (1997) Biochem. Biophys. Res. Commun. 231, 509-513. Takahashi, K. et al. (2001) J. Biol. Chem. 276, 37556-37563. Miller, D.W. et al. (2003) J. Biol. Chem. 278, 36588-36595. Cookson, M.R. (2005) Annu. Rev. Biochem. 74, 29-52. Moore, D.J. (2006) Biochem. Soc. Trans. 34, 749-753. |
