| Catalog Number | PT-5005a-9 |
| Product Id | PT-5005a-9 |
| Product Name | Rabbit anti-Human c-Myc IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Transcription Factors) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (KHKLEQLRNSCA) corresponding to amino acids 428-439 of human c-Myc. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot assays (1: 1,000 dilution) using the immunizing peptide. c-Myc is a transcription factor with apparent molecular weight of 62-67 kDa which plays an important role in the control of cell growth, cell cycle progression, neoplasia, and apoptotic cell death. It contains a basic helix-loop-helix leucine zipper domain required for dimerization and binds DNA as an heterodimer with MAX protein. c-Myc is overexpressed in different tumors such as colorectal, gastric, gallbladder, hepatic, mammary, pulmonary, prostatic, endocrine, as well as hematopoietic neoplasms. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Eisenman, R.N. (2001) Genes & Dev. 15, 2023-2030. Plengaris, S. & Khan, M. (2003) Arch. Biochem. Biophys. 416, 129-136.Knoepfler, P.S. (2007) Cancer Res. 67, 5061-6063. |
