| Catalog Number | PT-5010a-9 |
| Product Id | PT-5010a-9 |
| Product Name | Rabbit anti-Human L-Myc IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Transcription Factors) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (SQEEASERGPQE) corresponding to amino acids 224-235 of human L-Myc. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA and Western blot assays (1: 100 dilution) using the immunizing peptide. L-Myc is a nuclear protein with two molecular forms of 60 and 66 kDa and it plays a role in the control of cell growth, cell cycle progression, neoplasia, and apoptotic cell death. It contains a basic helix-loop-helix leucine zipper domain required for dimerization and binds DNA as an heterodimer with Max protein. Both molecular forms have been detected in some carcinoma cell lines. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | DePinho, R.A. et al. (1987) Genes & Dev. 1, 1311-1326. Nesbit, C-E. et al. (1999) Oncogene 18, 3004-3016. Knoepfler, P.S. et al. (2006) EMBO J. 25, 2723-2734. |
