| Catalog Number | PT-5030a-9 |
| Product Id | PT-5030a-9 |
| Product Name | Rabbit anti-Human Kaiso IgG fraction polyclonal antibody |
| Temperature | -20°C |
| Unit | 1mg |
| Price | 425 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Polyclonal Antibodies (Cancer/Transcription Factors) |
| Description | IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DGSTEFEFIIPESY) corresponding to amino acids 660-673 of human Kaiso. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | N/A |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This polyclonal antibody reacts in ELISA (1:50 dilution) using the immunizing peptide. Kaiso is a transcriptional represor that belongs to POZ-zinc finger family of transcription factors implicated in development and cancer. It binds to specific methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and it also binds to non-methylated consensus sequence 5'-CTGCNA-3'. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of represive chromatin structures in taget gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway. |
| Formulation | Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Daniel, J.M. & Reynolds, A.B. (1999) Mol. Cell. Biol. 19, 3614-3623. Soubry, A. et al. (2005) Cancer Res. 65, 2224-2233. Kelly, K.F. & Daniel J.M. (2006) Trends Cell. Biol. 16, 578-587. Daniel, J.M. (2007) Biochim. Biophys. Acta 1773, 59-68. |
