| Catalog Number | HNM-6042AZ1-5 |
| Product Name | Anti-Glycoprotein 1 of Seoul virus (SEOV). IgG fraction monoclonal antibody. Clone 2C8/B11 |
| Temperature | -20°C |
| Unit | 100µg |
| Price | 499 |
| Availability | Available |
| Category | Infectious Agents |
| Subcategory | Hantavirus |
| Description | Mouse monoclonal antibody IgG fraction (clone 2C8/B11) obtained by immunizing mice with purified recombinant SEOV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG-1 |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This antibody can be used in ELISA (1:10,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of SEOV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. SEOV is a hantavirus causing a mild to moderate form of hemorrhagic fever with renal syndrome that is distributed mainly in Asia and Europe. It is transmitted by the rodents Rattus rattus and Rattus norvegicus. |
| Formulation | Solution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Zhang, Y-Z et al. (2009) Emerg. Infect. Dis. 15, 200-206.
Lokugamage, N. et al. (2004) Microbiol. Immunol. 48, 843-851.
Kim, Y.S. et al. (1995) Nephon 71, 419-427.
Antic, D. et al. (1991) Virus Res. 19, 47-58.
Arikawa, J. et al. (1990) Virology 176, 114-125. |
