| Catalog Number | HNM-6052AZ1-5 |
| Product Name | Anti-Glycoprotein 1 of Hantaan virus (HTNV). IgG fraction monoclonal antibody. Clone 1F5/G2 |
| Temperature | -20°C |
| Unit | 100µg |
| Price | 499 |
| Availability | Available |
| Category | Infectious Agents |
| Subcategory | Hantavirus |
| Description | Mouse monoclonal antibody IgG fraction (clone 1F5/G2) obtained by immunizing mice with purified recombinant HTNV Glycoprotein 1 (G1). The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG-1 |
| Mol Weight | N/A |
| Purity | N/A |
| Storage | Store at -20ºC. |
| Stability | Stable at least one year at -20ºC. Avoid repeated freezing and thawing. |
| Biological Activity | This antibody can be used in ELISA (1:30,000 dilution) and Western blot (1:20,000 dilution) analysis. It recognizes specifically G1 glycoprotein of HTNV. Hantaviruses (family Bunyaviridae) are enveloped viruses that contain a tripartite, negative-stranded RNA genome encoding an RNA-dependent RNA polymerase (L), two integral membrane glycoproteins (G1 and G2), and a nucleocapsid (N) protein. The G1 and G2 glycoproteins form heterodimers and they attach the virion to a cell receptor and to promote fusion membrane after endocytosis of the virion. G1 can dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis. HTNV is a causative agent of severe hemorrhagic fever mainly in China and it is transmitted by the rodent Apodemus agrarius. |
| Formulation | Solution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial. |
| References | Yan, L. et al (2007) Emerg. Infect. Dis. 13, 1301-1306.
Löber, C. et al. (2001) Virology 289, 224-229.
Antic, D. et al. (1992) Virology 189, 324-328.
Yoo, D. & Kang, C.Y. (1987) Nucleic Acids Res. 15, 6299-6300. |
