| Catalog Number | MI-290-3 |
| Product Id | MI-290-3 |
| Product Name | Human recombinant MIP-1 alpha |
| Temperature | -80°C |
| Unit | 10µg |
| Price | 200 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Macrophage Inflammatory Proteins |
| Description | Macrophage Inflammatory Protein-1( (MIP-1 alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1 alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1 alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1 alpha is composed of 69 amino acid residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1 alpha is 60% homologous with human MIP-1 beta, 75% homologous with murine MIP-1 alpha, and has been shown to be active on murine cells. Human recombinant MIP-1 alpha is produced in genetically engineered yeast, and purified by sequential chromatography. |
| Isotype | N/A |
| Mol Weight | 8 KDa |
| Purity | Over 95% pure by SDS gel electrophoresis, with low level of endotoxin. |
| Storage | Store at -80°C. |
| Stability | Several months at -80°C. |
| Biological Activity | The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis. |
| Formulation | In water at a concentration of 1.0 mg protein/ml |
| References | 1Nathan, C.F. (1987)J. Clin. Invest. 79:319
2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612
3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911
2. Dunlop, et al (1992) Blood 79: 2221
3. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895 |
