| Catalog Number | TM-501-55 |
| Product Id | TM-501-55 |
| Product Name | Anti- human Sirtuin type 1 (SIRT 1) IgG fraction (monoclonal) |
| Temperature | -20°C |
| Unit | 150µg |
| Price | 425 |
| Availability | Available |
| Category | Proteins and Antibodies for Transcription Research |
| Subcategory | Proteins and Antibodies |
| Description | IgG fraction from mouse monoclonal antibody (clone 3H2/G8) obtained by immunization using an ovalbumin-conjugated synthetic peptide corresponding to aa551–aa599 of human silent information regulator 2 homolog (Sirt1) protein. The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG1 |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing. |
| Biological Activity | This antibody can be used for ELISA assay (1: 8,000 dilution), immunoblot and immunoprecipitation analysis. It recognizes Sirt1 (120kDa), a NAD-dependent p53 deacetylase; protein involved in diverse processes ranging from regulation of gene silencing to DNA damage response in mammalian cells. |
| Formulation | Solution at 1.0 mg/mL in PBS (pH 7.2). |
| References | Langley, E. et al. (2002) EMBO J. 21, 2383 – 2396.
Vaziri, H. et al. (2001) Cell 107, 149 – 159.
Frye, R. (1999) Biochem. Biophys. Res. Commun. 260, 273 – 279. |
