| Catalog Number | MR-1201-7 |
| Product Id | MR-1201-7 |
| Product Name | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase (RIP). IgG fraction (monoclonal) |
| Temperature | -20°C |
| Unit | 250µg |
| Price | 400 |
| Availability | Available |
| Category | Growth Factors, Cytokines, Receptors and their Antibodies |
| Subcategory | Monoclonal Antibodies (Growth Factors/Cytokines/Receptors) |
| Description | IgG fraction from mouse monoclonal antibody (clone 9G11/G4) obtained by immunization of mice with the recombinant N-terminal region of RIP (aa1 – aa430). The IgG fraction was purified using Protein G-Sepharose. |
| Isotype | IgG-2b |
| Storage | Store at -20°C. |
| Stability | Stable for at least one year. Avoid repeated freezing and thawing. |
| Biological Activity | This antibody can be used for ELISA assay (1:8,000 dilution) and Western Blot (1: 12,000 dilution). RIP is a serine/threonine kinase, component of the active TNF receptor 1 signaling complex. It contains three domains, including an N-terminal kinase domain (aa1 – aa300), an intermediate domain, and a C-terminal death domain. This protein is essential in DNA damage-induced NF-?-B activation and in TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling. |
| Formulation | Solution at 1.0 mg/mL in PBS |
| References | Meylan, E. et. al. (2004) Nat. Immunol. 5, 503 - 507.
Zhang, H-G. et. al. (2004) Oncogene 23, 2009 - 2015.
Hur, G.M. et. al. (2003) Genes & Dev. 17, 873 - 882.
Hsu, H. et. al. (1996) Immunity 4, 387 - 386. |
